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学术报告:Bioprinting: Implementation, Process Dynamics, and Process‐Induced Cell Injury

主讲人:黄勇教授 【佛罗里达大学盖恩斯维尔分校,机械与航天工程系教授】

时间:2019年2月27日上午10:30开始

地点:大学城校区工学二号馆202会议室

Abstract: Maskless (including extrusion-, laser-, and inkjet-based) three-dimensional (3D) cell bioprinting is a revolutionary advance for printing arbitrary cellular patterns as well as creating heterogeneous living constructs. More importantly, bioprinting provides a promising solution to the problem of organ donor shortage by providing printed tissue/organ constructs for transplantation, resulting in what is known as organ printing. While there are various technological advances for bioprinting, cell-laden viscoelastic fluid printing and printing-induced cell injury still pose significant challenges to ensuring the scale-up of robust bioprinting. Using laser bioprinting (laser-induced forward transfer) and inkjet bioprinting as two jet-based model printing systems, we have been studying the bioink jettability and printability as well as printing-induced cell injury problems, aiming to achieve robotic bioprinting. In this talk, the perspective of ongoing bioprinting research and various bioprinting technologies are first introduced. Then the jettability and printability of cell-laden viscoelastic bioinks are discussed using the dimensionless Ohnesorge and elasto-capillary numbers to capture the influence of material properties along with the Weber number to capture the influence of printing conditions. Furthermore, the modeling of laser-induced cellular droplet formation and landing processes is presented, and the relationship between the mechanical loading information and post-transfer cell injury/viability is established using an apoptosis signaling pathway-based modeling approach. Finally, this talk shares some thoughts regarding bioprinting-related basic scientific challenges.

 

Biography:

Dr. Yong Huang is a professor of Mechanical and Aerospace Engineering, Biomedical Engineering, and Materials Science and Engineering at the University of Florida, Gainesville, Florida. His research interests are two-fold: 1) processing of biological and engineering materials for healthcare/energy applications, and 2) understanding of dynamic material behavior during manufacturing and process-induced damage or defect structures. His current research topics include three-dimensional (3D) printing of biological and engineering structures, precision engineering of medical implants and performance evaluation of machined implants, and fabrication of polymeric microspheres / microcapsules / hollow fiber membranes. He served as the Technical Program Chair for the 2010 American Society of Mechanical Engineers International Manufacturing Science and Engineering Conference (ASME MSEC 2010) and the 2012 International Symposium on Flexible Automation (ISFA 2012). He received various awards for his manufacturing research contributions including the ASME Blackall Machine Tool and Gage Award (2005), the Society of Manufacturing Engineers Outstanding Young Manufacturing Engineer Award (2006), the NSF CAREER Award (2008), and the ASME International Symposium on Flexible Automation Young Investigator Award (2008). He received his Ph.D. in Mechanical Engineering from the Georgia Institute of Technology in 2002 and is a Fellow of ASME.

个人简介:黄勇教授,现任佛罗里达大学盖恩斯维尔分校机械与航天工程系、生物医学工程系以及材料科学与工程系教授。主要从事生物与工程材料加工、工艺损伤与缺陷结构研究等领域的研究。目前,黄勇教授主要研究方向包括生物与工程结构3D打印、医学植入体精密工程与机加工植入物性能评估,以及高聚物功能微球/微胶囊包裹体/孔洞纤维膜的制造。黄勇教授于2002年12月取得美国佐治亚理工学院机械工程博士学位,目前是美国机械工程师学会会士(ASME Fellow)。曾任美国机械工程师协会2010年国际制造科学与工程大会(ASME MSEC 2010)和2012年柔性自动化国际研讨会(ISFA 2012)技术委员会主席。黄博士在制造工程领域的贡献为其获得了多项奖项,包括ASME Blackall Machine Tool and Gage Award (2005,布来科尔机器工具与器具ASME年度最佳论文奖。注:ASME制造工程期刊每年仅选出一篇获奖论文),美国制造工程师学会“杰出青年制造工程师奖” (2006),美国国家科学基金会“基金会杰出青年教授奖”(2008)以及美国机械工程师协会柔性自动化国际研讨会“青年研究者奖”(2008)等多个奖项。

 

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